Silvia Pulido, PhD

Dr. Pulido’s research interests center around clinical mass spectrometry and identifying novel proteomic drug targets and biomarkers that mark the onset of disease. Dr. Pulido has more than eighteen years of experience in pharmaceutical drug discovery research in the U.S. and Switzerland, has worked as a nurse aid and hospital phlebotomist, and as an environmental analytical chemist and microbiologist for Bionetics Corporation, a subcontractor to NASA. Dr. Pulido currently consults in clinical trial research design and scientific and technical writing. She has a PhD in Biochemistry.


Funded Research

  • Visiting Scientist Award, 2005, Ion Cyclotron Resonance Facility, National High Magnetic Field Laboratory

  • Schering AG Senior Scientist and National Institute of Health Research Fellow, 2001-2005, UVA Medical School

  • National Science Foundation Research Training Grant Postdoctoral Fellowship, 1998-2001, National High Magnetic Field Laboratory

  • Fondacion National Recherche Suisse Postdoctoral Fellowship Award, 1998, University of Geneva School of Medicine

  • Association Francaise contre les Maladies Musculaires Postdoctoral Award, 1996-1998, University of Lausanne Department of Pharmacology

  • Patricia B. Roberts Predoctoral Minority Fellowship Award, 1992-1996, Boston University Medical School

  • National Science Foundation Predoctoral Fellowship Grantwriting Competition, Honorable Mention, 1992-1996, Boston University Medical School

  • Notre Dame Academic Minority Scholarship for the Study of Science, 1984-1988, University of Notre Dame

Selected Publications

  • Domagala, A; Pulido, S; Kamieniczna, M; Kurpisz, M; Herr, JC. (2011). An isoimmune response to human sperm clathrin in an infertile woman with systemic lupus erythematosus. Journal of Reproductive Immunology, I(1), 95-98.

  • Li, YF; He, W; Kim, YH; Mandal, A; Vanage, G; Pulido, S; Digilio, L; Klotz, K; Flickinger, CJ; Herr, JC. (2008). Polymorphic CABYR expressed in the late steps of spermiogenesis and binds with AKAP3, AKAP4 and ropporin in mouse sperm fibrous sheath. Journal of Urology, 79(4), 618-61.

  • Xu B, Hao Z, Jha KN, Zhang Z, Urekar C, Digilio L, Pulido S, Strauss JF 3rd,Flickinger CJ, Herr JC. (2008).Targeted deletion of Tssk1 and 2 causes male infertility due to haploid insufficiency. Developmental Biology, 319(2), 211-22.

  • Xu B, Hao Z, Jha KN, Zhang Z, Urekar C, Digilio L, Pulido S, Strauss JF 3rd,Flickinger CJ, Herr JC. (2008). TSKS concentrates in spermatid centrioles during flagellogenesis. Developmental Biology, 319(2), 201-10.

  • Li YF, He W, Jha KN, Klotz K, Kim YH, Mandal A, Pulido S,Digilio L, Flickinger CJ, Herr JC. (2007). FSCB, a novel protein kinase A-phosphorylated calcium-binding protein, is a CABYR-binding partner involved in late steps of fibrous sheath biogenesis. Journal of Biological Chemistry, 282(47), 34104-19.

  • Xu B, Hao Z, Jha KN, Digilio L, Urekar C, Kim YH, Pulido S, Flickinger CJ, Herr JC. (2007). Validation of a testis spe- cific serine/threonine kinase [TSSK] family and the substrate of TSSK1 & 2, TSKS, as contraceptive targets. Society of Reproduction and Fertility Supplement, 63, 87-101.

  • Domagala A, Pulido S, Kurpisz M, Herr JC. (2007). Application of proteomic methods for identification of sperm immunogenic antigens. Molecular Human Reproductivity, 13(7), 437-44.

  • Kim, YH; Sen, B; Vanage, G; Mandal, A; Wolkowicz, MJ; Pulido, S; Klotz, K;    Hao, ZL; Flickinger, CJ; Herr, JC. (2004). Polymorphic CABYR coding region A (CR-A) and coding region B (CR-B) are expressed in mouse sperm and localize to the fibrous sheath. Biological Reproductivity, 252, 53.

  • Hao, ZL; Xu, BF; Kim, YH; Digilio, L; Pulido, S; Westbrook, A; Stoler, M; Visconti, P; Flickinger, C; Herr, JC. (2003)Gene expression studies of two members of the mammalian testis specific serine/threonine kinase subfamily (TSSK2, TSSK4) and a substrate (TSKS). Biological Reproductivity, 186, 87.

Professional Organizations

  • Federation of American Societies for Experimental Biology
  • American Society for Cellular and Molecular Biologists                             
  • American Chemical Society
  • American Society for Mass Spectrometry
  • Swiss Society of Pharmacology and Toxicology

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Contact Info


  • Assistant Director of Research Programs and Services